RRC ID 11771
Author Takahashi E, Niimi K, Itakura C.
Title Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
Journal Behav. Brain Res.
Abstract Aged heterozygous Rolling Nagoya mice carrying Cav2.1alpha1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1alpha1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances.
Volume 204(1)
Pages 241-5
Published 2009-12-1
DOI 10.1016/j.bbr.2009.05.020
PII S0166-4328(09)00334-9
PMID 19467269
MeSH Aging* Analysis of Variance Animals Calcium Channels, N-Type / genetics Calcium Channels, N-Type / metabolism* Genotype Hippocampus / physiology* Hippocampus / physiopathology Male Memory Disorders / physiopathology Memory, Short-Term / physiology* Mice Mice, Mutant Strains Mutation Neuropsychological Tests RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Space Perception / physiology* Temporal Lobe / physiology* Temporal Lobe / physiopathology
IF 2.77
Times Cited 4
Mice PROD-rol/+