Reference - Detail
| RRC ID | 11857 |
|---|---|
| Author | Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. |
| Title | Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. |
| Journal | Neurosci Lett |
| Abstract |
Hallucinogenic drugs, including mescaline, psilocybin and lysergic acid diethylamide (LSD), act at serotonin 5-HT2A receptors (5-HT2ARs). Metabotropic glutamate receptor 2/3 (mGluR2/3) ligands show efficacy in modulating the responses induced by activation of 5-HT2ARs. The formation of a 5-HT2AR-mGluR2 complex suggests a functional interaction that affects the hallucinogen-regulated cellular signaling pathways. Here, we tested the cellular and behavioral effects of hallucinogenic 5-HT2AR agonists in mGluR2 knockout (mGluR2-KO) mice. Mice were intraperitoneally injected with the hallucinogens DOI (2 mg/kg) and LSD (0.24 mg/kg), or vehicle. Head-twitch behavioral response, expression of c-fos, which is induced by all 5-HT2AR agonists, and expression of egr-2, which is hallucinogen-specific, were determined in wild type and mGluR2-KO mice. [(3)H]Ketanserin binding displacement curves by DOI were performed in mouse frontal cortex membrane preparations. Head twitch behavior was abolished in mGluR2-KO mice. The high-affinity binding site of DOI was undetected in mGluR2-KO mice. The hallucinogen DOI induced c-fos in both wild type and mGluR2-KO mice. However, the induction of egr-2 by DOI was eliminated in mGlu2-KO mice. These findings suggest that the 5-HT2AR-mGluR2 complex is necessary for the neuropsychological responses induced by hallucinogens. |
| Volume | 493(3) |
| Pages | 76-9 |
| Published | 2011-4-15 |
| DOI | 10.1016/j.neulet.2011.01.046 |
| PII | S0304-3940(11)00092-9 |
| PMID | 21276828 |
| PMC | PMC3064746 |
| MeSH | Animals Behavior, Animal / drug effects Behavior, Animal / physiology* Early Growth Response Protein 2 / biosynthesis Early Growth Response Protein 2 / physiology Frontal Lobe / drug effects Frontal Lobe / physiology Genes, fos / physiology Hallucinogens / metabolism* Hallucinogens / toxicity Male Mice Mice, 129 Strain Mice, Knockout Protein Binding / drug effects Protein Binding / physiology Receptor, Serotonin, 5-HT2A / deficiency Receptor, Serotonin, 5-HT2A / physiology* Receptors, Metabotropic Glutamate / metabolism* Schizophrenia / chemically induced Schizophrenia / metabolism Serotonin 5-HT2 Receptor Agonists / metabolism* Serotonin 5-HT2 Receptor Agonists / toxicity Signal Transduction / drug effects Signal Transduction / physiology |
| IF | 2.274 |
| Times Cited | 118 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
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| The most frequently cited source | |
| Total number of mentions | 96 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Mice | RBRC01351 |