RRC ID 12135
Author Agetsuma M, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, Sassa T, Amo R, Shiraki T, Kawakami K, Hosoya T, Higashijima S, Okamoto H.
Title The habenula is crucial for experience-dependent modification of fear responses in zebrafish.
Journal Nat Neurosci
Abstract The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
Volume 13(11)
Pages 1354-6
Published 2010-11-1
DOI 10.1038/nn.2654
PII nn.2654
PMID 20935642
MeSH Adaptation, Physiological / physiology Amino Acids / metabolism Analysis of Variance Animals Animals, Genetically Modified Behavior, Animal Carbocyanines / metabolism Conditioning, Classical / physiology DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism Electroshock / adverse effects Fear / physiology* Gene Expression Regulation / physiology* Green Fluorescent Proteins / genetics HSP72 Heat-Shock Proteins / genetics Habenula / cytology Habenula / metabolism Habenula / physiology* In Situ Nick-End Labeling Larva Locomotion / physiology Neural Pathways / physiology Neurons / metabolism RNA, Messenger / metabolism Time Factors Transcription Factor Brn-3A / genetics Tryptophan Hydroxylase / genetics Tryptophan Hydroxylase / metabolism Zebrafish / physiology* Zebrafish Proteins / genetics Zebrafish Proteins / metabolism*
IF 20.071
Times Cited 186
Zebrafish rw0110b (Tg (brn3a-hsp70:GFP ))