RRC ID 12141
Author Del Bene F, Wyart C, Robles E, Tran A, Looger L, Scott EK, Isacoff EY, Baier H.
Title Filtering of visual information in the tectum by an identified neural circuit.
Journal Science
Abstract The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter γ-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with KillerRed, or silencing of their synaptic transmission, eliminates the size tuning of deeper layers and impairs the capture of prey.
Volume 330(6004)
Pages 669-73
Published 2010-10-29
DOI 10.1126/science.1192949
PII 330/6004/669
PMID 21030657
PMC PMC3243732
MeSH Animals Animals, Genetically Modified Axons / physiology Bicuculline / pharmacology Dendrites / physiology GABA Antagonists / pharmacology Interneurons / physiology* Neural Inhibition Neurons / physiology* Neuropil / physiology Optic Lobe, Nonmammalian / cytology Optic Lobe, Nonmammalian / physiology* Photic Stimulation Retina / physiology* Retinal Neurons / physiology Synaptic Transmission Visual Pathways / physiology* Visual Perception* Zebrafish gamma-Aminobutyric Acid / metabolism
IF 41.063
Times Cited 93
Zebrafish Tol2 TeTxLC-CFP