| RRC ID |
12324
|
| Author |
Shirai T, Yorimitsu T, Kiritooshi N, Matsuzaki F, Nakagoshi H.
|
| Title |
Notch signaling relieves the joint-suppressive activity of Defective proventriculus in the Drosophila leg.
|
| Journal |
Dev Biol
|
| Abstract |
Segmentation plays crucial roles during morphogenesis. Drosophila legs are divided into segments along the proximal-distal axis by flexible structures called joints. Notch signaling is necessary and sufficient to promote leg growth and joint formation, and is activated in distal cells of each segment in everting prepupal leg discs. The homeobox gene defective proventriculus (dve) is expressed in regions both proximal and distal to the intersegmental folds at 4 h after puparium formation (APF). Dve-expressing region partly overlaps with the Notch-activated region, and they become a complementary pattern at 6 h APF. Interestingly, dve mutant legs resulted in extra joint formation at the center of each tarsal segment, and the forced expression of dve caused a jointless phenotype. We present evidence that Dve suppresses the potential joint-forming activity, and that Notch signaling represses Dve expression to form joints.
|
| Volume |
312(1)
|
| Pages |
147-56
|
| Published |
2007-12-1
|
| DOI |
10.1016/j.ydbio.2007.09.003
|
| PII |
S0012-1606(07)01339-5
|
| PMID |
17950268
|
| MeSH |
Animals
Cell Polarity
Drosophila Proteins / metabolism*
Drosophila melanogaster / cytology
Drosophila melanogaster / embryology*
Drosophila melanogaster / genetics
Drosophila melanogaster / metabolism*
ErbB Receptors / metabolism
Extremities / embryology*
Gene Expression Regulation, Developmental
Homeodomain Proteins / metabolism*
Joints / cytology
Joints / embryology
Joints / metabolism*
Models, Biological
Mutation / genetics
Phenotype
Receptors, Notch / metabolism*
Signal Transduction*
Time Factors
|
| IF |
2.896
|
| Times Cited |
19
|
|
WOS Category
|
DEVELOPMENTAL BIOLOGY
|
| Resource |
| Drosophila |
NP4281 (DGRC#113424) |
