Reference - Detail
|Author||Kashiwazaki J, Nakamura T, Iwaki T, Takegawa K, Shimoda C.|
|Title||A role for fission yeast Rab GTPase Ypt7p in sporulation.|
|Journal||Cell Struct. Funct.|
Ypt7p, a fission yeast (Schizosaccharomyces pombe) homologue of Rab7 GTPase, mediates fusion of endosomes to vacuoles and homotypic vacuole fusion. Here, we report that Ypt7p plays important roles in sporulation. Most ypt7Delta asci produced less than four spores, which were apparently immature and germinated at low frequency. Furthermore, ypt7Delta cells were defective in development of the forespore membranes. Vacuoles in sporulating cells were found to undergo extensive homotypic vacuole fusion to form a few large compartments occupying the entire cytoplasm of asci. This extensive vacuole fusion depended on Ypt7p.
|MeSH||Gene Expression Regulation, Fungal Membrane Fusion / genetics Membrane Fusion / physiology* Microscopy, Fluorescence Mutation Saccharomyces cerevisiae Proteins / genetics Saccharomyces cerevisiae Proteins / metabolism Saccharomyces cerevisiae Proteins / physiology* Schizosaccharomyces / cytology Schizosaccharomyces / genetics Schizosaccharomyces / metabolism* Spores, Fungal / physiology* Vacuoles / physiology rab GTP-Binding Proteins / genetics rab GTP-Binding Proteins / metabolism rab GTP-Binding Proteins / physiology*|
|WOS Category||CELL BIOLOGY|
|Yeast||MKW5 KJ100-7B(Y) YN68 ?|