| RRC ID |
12684
|
| Author |
Kagami A, Sakuno T, Yamagishi Y, Ishiguro T, Tsukahara T, Shirahige K, Tanaka K, Watanabe Y.
|
| Title |
Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.
|
| Journal |
EMBO Rep
|
| Abstract |
In fission yeast, meiotic mono-orientation of sister kinetochores is established by cohesion at the core centromere, which is established by a meiotic cohesin complex and the kinetochore protein Moa1. The cohesin subunit Psm3 is acetylated by Eso1 and deacetylated by Clr6. We show that in meiosis, Eso1 is required for establishing core centromere cohesion during S phase, whereas Moa1 is required for maintaining this cohesion after S phase. The clr6-1 mutation suppresses the mono-orientation defect of moa1Δ cells, although the Clr6 target for this suppression is not Psm3. Thus, several acetylations are crucial for establishing and maintaining core centromere cohesion.
|
| Volume |
12(11)
|
| Pages |
1189-95
|
| Published |
2011-10-28
|
| DOI |
10.1038/embor.2011.188
|
| PII |
embor2011188
|
| PMID |
21979813
|
| PMC |
PMC3207105
|
| MeSH |
Acetylation
DNA Replication
Meiosis*
Meiotic Prophase I
Models, Biological
Mutation / genetics
Protein Subunits / metabolism
Schizosaccharomyces / cytology*
Schizosaccharomyces / metabolism*
Schizosaccharomyces pombe Proteins / metabolism
|
| IF |
7.497
|
| Times Cited |
17
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Yeast |
strains? |
