論文 - 詳細
| RRC ID | 1283 |
|---|---|
| 著者 | Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA. |
| タイトル | E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53. |
| ジャーナル | Mol Cancer Res |
| Abstract |
E2FBP1/DRIL1 is an AT-rich interaction domain DNA-binding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection between E2FBP1/DRIL1 and the p53 tumor suppressor, a key regulator of growth arrest or apoptosis in response to cellular stress. We found a putative p53-binding site, which specifically responded to p53, in the second intron of the E2FBP1/DRIL1 gene. E2FBP1/DRIL1was induced by p53 and up-regulated following DNA damage caused by UV radiation or doxorubicin treatment in a manner dependent on endogenous p53. The ectopic expression of E2FBP1/DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53. |
| 巻・号 | 1(6) |
| ページ | 438-44 |
| 公開日 | 2003-4-1 |
| PMID | 12692263 |
| MeSH | AT Rich Sequence / genetics* Base Sequence Cell Division Cell Line, Tumor Cyclin D1 / metabolism DNA Damage DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics* DNA-Binding Proteins / metabolism* Humans Introns / genetics Molecular Sequence Data Oncogenes / genetics* Protein Binding Protein Structure, Tertiary RNA, Messenger / genetics RNA, Messenger / metabolism Trans-Activators* Transcription Factors Transcription, Genetic / genetics Tumor Suppressor Protein p53 / metabolism* |
| IF | 4.63 |
| 引用数 | 21 |
| WOS 分野 | ONCOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) Saos-2(RCB0428) |