| RRC ID |
1283
|
| 著者 |
Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA.
|
| タイトル |
E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.
|
| ジャーナル |
Mol Cancer Res
|
| Abstract |
E2FBP1/DRIL1 is an AT-rich interaction domain DNA-binding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection between E2FBP1/DRIL1 and the p53 tumor suppressor, a key regulator of growth arrest or apoptosis in response to cellular stress. We found a putative p53-binding site, which specifically responded to p53, in the second intron of the E2FBP1/DRIL1 gene. E2FBP1/DRIL1was induced by p53 and up-regulated following DNA damage caused by UV radiation or doxorubicin treatment in a manner dependent on endogenous p53. The ectopic expression of E2FBP1/DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53.
|
| 巻・号 |
1(6)
|
| ページ |
438-44
|
| 公開日 |
2003-4-1
|
| PMID |
12692263
|
| MeSH |
AT Rich Sequence / genetics*
Base Sequence
Cell Division
Cell Line, Tumor
Cyclin D1 / metabolism
DNA Damage
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / genetics*
DNA-Binding Proteins / metabolism*
Humans
Introns / genetics
Molecular Sequence Data
Oncogenes / genetics*
Protein Binding
Protein Structure, Tertiary
RNA, Messenger / genetics
RNA, Messenger / metabolism
Trans-Activators*
Transcription Factors
Transcription, Genetic / genetics
Tumor Suppressor Protein p53 / metabolism*
|
| IF |
4.63
|
| 引用数 |
21
|
|
WOS 分野
|
ONCOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
A549(RCB0098)
Saos-2(RCB0428) |
