Reference - Detail
|Author||Wolf MJ, Rockman HA.|
|Title||Drosophila, genetic screens, and cardiac function.|
The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century, but only over the past few decades has this tremendous resource been the focus of cardiovascular research. Fly genetics offers sophisticated transgenic systems, molecularly defined genomic deficiencies, genome-wide transgenic RNAi lines, and numerous curated mutants to perform genetic screens. As a genetically tractable model, the fly facilitates gene discovery and can complement mammalian models of disease. The circulatory system in the fly comprises well-defined sets of cardiomyocytes, and methodological advances have permitted accurate characterization of cardiac morphology and function. Thus, fly genetics and genomics offer new approaches for gene discovery of adult cardiac phenotypes to identify evolutionarily conserved molecular signals that drive cardiovascular disease.
|MeSH||Animals Animals, Genetically Modified Cardiovascular Diseases / genetics* Cardiovascular Diseases / metabolism Cardiovascular Diseases / physiopathology Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental Genetic Engineering* Genetic Predisposition to Disease Genetic Testing* Humans Morphogenesis / genetics Phenotype|
|WOS Category||CARDIAC & CARDIOVASCULAR SYSTEMS PERIPHERAL VASCULAR DISEASE HEMATOLOGY|