RRC ID 15370
Author Wolf MJ, Rockman HA.
Title Drosophila, genetic screens, and cardiac function.
Journal Circ. Res.
Abstract The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century, but only over the past few decades has this tremendous resource been the focus of cardiovascular research. Fly genetics offers sophisticated transgenic systems, molecularly defined genomic deficiencies, genome-wide transgenic RNAi lines, and numerous curated mutants to perform genetic screens. As a genetically tractable model, the fly facilitates gene discovery and can complement mammalian models of disease. The circulatory system in the fly comprises well-defined sets of cardiomyocytes, and methodological advances have permitted accurate characterization of cardiac morphology and function. Thus, fly genetics and genomics offer new approaches for gene discovery of adult cardiac phenotypes to identify evolutionarily conserved molecular signals that drive cardiovascular disease.
Volume 109(7)
Pages 794-806
Published 2011-9-16
DOI 10.1161/CIRCRESAHA.111.244897
PII 109/7/794
PMID 21921272
PMC PMC3678974
MeSH Animals Animals, Genetically Modified Cardiovascular Diseases / genetics* Cardiovascular Diseases / metabolism Cardiovascular Diseases / physiopathology Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental Genetic Engineering* Genetic Predisposition to Disease Genetic Testing* Humans Morphogenesis / genetics Phenotype
IF 15.862
Times Cited 25
WOS Category CARDIAC & CARDIOVASCULAR SYSTEMS PERIPHERAL VASCULAR DISEASE HEMATOLOGY
Resource
INFORMATION http://www.dgrc.kit.ac.jp/en/index.html
Drosophila