論文 - 詳細
| RRC ID | 15405 |
|---|---|
| 著者 | Goossens T, Kang YY, Wuytens G, Zimmermann P, Callaerts-Végh Z, Pollarolo G, Islam R, Hortsch M, Callaerts P. |
| タイトル | The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. |
| ジャーナル | Development |
| Abstract |
The spatiotemporal integration of adhesion and signaling during neuritogenesis is an important prerequisite for the establishment of neuronal networks in the developing brain. In this study, we describe the role of the L1-type CAM Neuroglian protein (NRG) in different steps of Drosophila mushroom body (MB) neuron axonogenesis. Selective axon bundling in the peduncle requires both the extracellular and the intracellular domain of NRG. We uncover a novel role for the ZO-1 homolog Polychaetoid (PYD) in axon branching and in sister branch outgrowth and guidance downstream of the neuron-specific isoform NRG-180. Furthermore, genetic analyses show that the role of NRG in different aspects of MB axonal development not only involves PYD, but also TRIO, SEMA-1A and RAC1. |
| 巻・号 | 138(8) |
| ページ | 1595-605 |
| 公開日 | 2011-4-1 |
| DOI | 10.1242/dev.052787 |
| PII | dev.052787 |
| PMID | 21389050 |
| PMC | PMC3062427 |
| MeSH | Animals Axons / metabolism* Axons / physiology Cell Adhesion Molecules, Neuronal / genetics Cell Adhesion Molecules, Neuronal / metabolism* Cell Line Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Female Immunohistochemistry Male Mushroom Bodies / cytology* Mushroom Bodies / metabolism* Neural Cell Adhesion Molecule L1 / genetics Neural Cell Adhesion Molecule L1 / metabolism* Organogenesis / genetics Organogenesis / physiology Polymerase Chain Reaction Signal Transduction / genetics Signal Transduction / physiology |
| IF | 5.611 |
| 引用数 | 19 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | pyd[LL04525] was obtained from the Drosophila Genetic Resource Center (Kyoto Japan). |