| RRC ID |
15405
|
| 著者 |
Goossens T, Kang YY, Wuytens G, Zimmermann P, Callaerts-Végh Z, Pollarolo G, Islam R, Hortsch M, Callaerts P.
|
| タイトル |
The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development.
|
| ジャーナル |
Development
|
| Abstract |
The spatiotemporal integration of adhesion and signaling during neuritogenesis is an important prerequisite for the establishment of neuronal networks in the developing brain. In this study, we describe the role of the L1-type CAM Neuroglian protein (NRG) in different steps of Drosophila mushroom body (MB) neuron axonogenesis. Selective axon bundling in the peduncle requires both the extracellular and the intracellular domain of NRG. We uncover a novel role for the ZO-1 homolog Polychaetoid (PYD) in axon branching and in sister branch outgrowth and guidance downstream of the neuron-specific isoform NRG-180. Furthermore, genetic analyses show that the role of NRG in different aspects of MB axonal development not only involves PYD, but also TRIO, SEMA-1A and RAC1.
|
| 巻・号 |
138(8)
|
| ページ |
1595-605
|
| 公開日 |
2011-4-1
|
| DOI |
10.1242/dev.052787
|
| PII |
dev.052787
|
| PMID |
21389050
|
| PMC |
PMC3062427
|
| MeSH |
Animals
Axons / metabolism*
Axons / physiology
Cell Adhesion Molecules, Neuronal / genetics
Cell Adhesion Molecules, Neuronal / metabolism*
Cell Line
Drosophila
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Female
Immunohistochemistry
Male
Mushroom Bodies / cytology*
Mushroom Bodies / metabolism*
Neural Cell Adhesion Molecule L1 / genetics
Neural Cell Adhesion Molecule L1 / metabolism*
Organogenesis / genetics
Organogenesis / physiology
Polymerase Chain Reaction
Signal Transduction / genetics
Signal Transduction / physiology
|
| IF |
5.611
|
| 引用数 |
19
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
pyd[LL04525] was obtained from the Drosophila Genetic Resource Center (Kyoto
Japan). |
