論文 - 詳細
| RRC ID | 15543 |
|---|---|
| 著者 | Willecke M, Toggweiler J, Basler K. |
| タイトル | Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. |
| ジャーナル | Oncogene |
| Abstract |
Tumorigenesis is a complex process, which requires alterations in several tumor suppressor or oncogenes. Here, we use a Drosophila tumor model to identify genes, which are specifically required for tumor growth. We found that reduction of phosphoinositide 3-kinase (PI3K) activity resulted in very small tumors while only slightly affecting growth of wild-type tissue. The observed inhibition on tumor growth occurred at the level of cell-cycle progression. We conclude that tumor cells become dependent on PI3K function and that reduction of PI3K activity synthetically interferes with tumor growth. The results presented here broaden our insights into the intricate mechanisms underling tumorigenesis and illustrate the power of Drosophila genetics in revealing weak points of tumor progression. |
| 巻・号 | 30(39) |
| ページ | 4067-74 |
| 公開日 | 2011-9-29 |
| DOI | 10.1038/onc.2011.125 |
| PII | onc2011125 |
| PMID | 21516128 |
| MeSH | Animals Cell Cycle* Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Cell Proliferation Disease Models, Animal Drosophila / enzymology Drosophila / metabolism* Janus Kinases / metabolism Neoplasms / genetics Neoplasms / metabolism* Neoplasms / pathology* Phosphatidylinositol 3-Kinases / deficiency Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / metabolism* RNA Interference RNA, Small Interfering STAT Transcription Factors / metabolism Signal Transduction* |
| IF | 7.971 |
| 引用数 | 28 |
| WOS 分野 | GENETICS & HEREDITY ONCOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | 1081R-2 5092R-2 |