論文 - 詳細
| RRC ID | 15736 |
|---|---|
| 著者 | Tobita K, Yanaka H, Otani H. |
| タイトル | Heat-treated Lactobacillus crispatus KT strains reduce allergic symptoms in mice. |
| ジャーナル | J Agric Food Chem |
| Abstract |
In the current study, we investigated the effects of heat-treated Lactobacillus crispatus KT strains on allergic response in mice. We found that the number of interferon (IFN)-gamma(+)CD4(+) cells was higher in C3H/HeN mouse spleen cultures incubated with L. crispatus KT strains than in those cultured with Lactobacillus JCM type cultures. The serum immunoglobulin E levels in NC/Nga mice that were administered KT strains were lower than those in the mice that were not given any bacterium. The ratio of spleen IFN-gamma(+)CD4(+)/interleukin-4(+)CD4(+) was highest in mice given L. crispatus KT-11. L. crispatus KT-11 also increased the expression of Toll-like receptor (TLR) 2, nucleotide-binding oligomerization domain (NOD) 1, and NOD2 in C3H/HeN mouse Peyer's patch cells. These results suggest that the L. crispatus KT-11 strain reduces allergic symptoms in NC/Nga mice via the adjustment of the type 1 helper T cell and type 2 helper T cell balance via TLR2, NOD1, and NOD2. |
| 巻・号 | 57(12) |
| ページ | 5586-90 |
| 公開日 | 2009-6-24 |
| DOI | 10.1021/jf900703q |
| PMID | 19469537 |
| MeSH | Animals CD4-Positive T-Lymphocytes / immunology Cells, Cultured Disease Models, Animal Gene Expression Hot Temperature Humans Hypersensitivity / genetics Hypersensitivity / immunology* Hypersensitivity / microbiology Immunoglobulin E / blood Lactobacillus / immunology* Male Mice Mice, Inbred C3H Peyer's Patches / immunology Probiotics / administration & dosage* Spleen / immunology* Th1 Cells / immunology Th2 Cells / immunology Toll-Like Receptor 2 / genetics Toll-Like Receptor 2 / immunology |
| IF | 4.192 |
| 引用数 | 24 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1132 JCM 1149 JCM 1185 JCM 2009 |