Reference - Detail
| RRC ID | 15736 |
|---|---|
| Author | Tobita K, Yanaka H, Otani H. |
| Title | Heat-treated Lactobacillus crispatus KT strains reduce allergic symptoms in mice. |
| Journal | J Agric Food Chem |
| Abstract |
In the current study, we investigated the effects of heat-treated Lactobacillus crispatus KT strains on allergic response in mice. We found that the number of interferon (IFN)-gamma(+)CD4(+) cells was higher in C3H/HeN mouse spleen cultures incubated with L. crispatus KT strains than in those cultured with Lactobacillus JCM type cultures. The serum immunoglobulin E levels in NC/Nga mice that were administered KT strains were lower than those in the mice that were not given any bacterium. The ratio of spleen IFN-gamma(+)CD4(+)/interleukin-4(+)CD4(+) was highest in mice given L. crispatus KT-11. L. crispatus KT-11 also increased the expression of Toll-like receptor (TLR) 2, nucleotide-binding oligomerization domain (NOD) 1, and NOD2 in C3H/HeN mouse Peyer's patch cells. These results suggest that the L. crispatus KT-11 strain reduces allergic symptoms in NC/Nga mice via the adjustment of the type 1 helper T cell and type 2 helper T cell balance via TLR2, NOD1, and NOD2. |
| Volume | 57(12) |
| Pages | 5586-90 |
| Published | 2009-6-24 |
| DOI | 10.1021/jf900703q |
| PMID | 19469537 |
| MeSH | Animals CD4-Positive T-Lymphocytes / immunology Cells, Cultured Disease Models, Animal Gene Expression Hot Temperature Humans Hypersensitivity / genetics Hypersensitivity / immunology* Hypersensitivity / microbiology Immunoglobulin E / blood Lactobacillus / immunology* Male Mice Mice, Inbred C3H Peyer's Patches / immunology Probiotics / administration & dosage* Spleen / immunology* Th1 Cells / immunology Th2 Cells / immunology Toll-Like Receptor 2 / genetics Toll-Like Receptor 2 / immunology |
| IF | 4.192 |
| Times Cited | 24 |
| WOS Category | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 1132 JCM 1149 JCM 1185 JCM 2009 |