| RRC ID |
15736
|
| 著者 |
Tobita K, Yanaka H, Otani H.
|
| タイトル |
Heat-treated Lactobacillus crispatus KT strains reduce allergic symptoms in mice.
|
| ジャーナル |
J Agric Food Chem
|
| Abstract |
In the current study, we investigated the effects of heat-treated Lactobacillus crispatus KT strains on allergic response in mice. We found that the number of interferon (IFN)-gamma(+)CD4(+) cells was higher in C3H/HeN mouse spleen cultures incubated with L. crispatus KT strains than in those cultured with Lactobacillus JCM type cultures. The serum immunoglobulin E levels in NC/Nga mice that were administered KT strains were lower than those in the mice that were not given any bacterium. The ratio of spleen IFN-gamma(+)CD4(+)/interleukin-4(+)CD4(+) was highest in mice given L. crispatus KT-11. L. crispatus KT-11 also increased the expression of Toll-like receptor (TLR) 2, nucleotide-binding oligomerization domain (NOD) 1, and NOD2 in C3H/HeN mouse Peyer's patch cells. These results suggest that the L. crispatus KT-11 strain reduces allergic symptoms in NC/Nga mice via the adjustment of the type 1 helper T cell and type 2 helper T cell balance via TLR2, NOD1, and NOD2.
|
| 巻・号 |
57(12)
|
| ページ |
5586-90
|
| 公開日 |
2009-6-24
|
| DOI |
10.1021/jf900703q
|
| PMID |
19469537
|
| MeSH |
Animals
CD4-Positive T-Lymphocytes / immunology
Cells, Cultured
Disease Models, Animal
Gene Expression
Hot Temperature
Humans
Hypersensitivity / genetics
Hypersensitivity / immunology*
Hypersensitivity / microbiology
Immunoglobulin E / blood
Lactobacillus / immunology*
Male
Mice
Mice, Inbred C3H
Peyer's Patches / immunology
Probiotics / administration & dosage*
Spleen / immunology*
Th1 Cells / immunology
Th2 Cells / immunology
Toll-Like Receptor 2 / genetics
Toll-Like Receptor 2 / immunology
|
| IF |
4.192
|
| 引用数 |
24
|
|
WOS 分野
|
AGRICULTURE, MULTIDISCIPLINARY
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
|
| リソース情報 |
| 一般微生物 |
JCM 1132
JCM 1149
JCM 1185
JCM 2009 |
