論文 - 詳細
| RRC ID | 18643 |
|---|---|
| 著者 | Sugiyama T, Takahashi K, Tokoro S, Gotou T, Neri P, Mori H. |
| タイトル | Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression. |
| ジャーナル | Innate Immun |
| Abstract |
The effect of 10-hydroxy-trans-2-decenoic acid (10H2DA), a major fatty acid component of royal jelly, was investigated on LPS-induced cytokine production in murine macrophage cell line, RAW264 cells. 10H2DA inhibited LPS-induced IL-6 production dose-dependently, but did not inhibit TNF-α production. 10H2DA inhibited LPS-induced NF-κB activation in a dose-dependent fashion. In addition, NF-κB activation induced by over-expression of either MyD88 or Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) was also inhibited by 10H2DA. Degradation of IκB-α and phosphorylation of IκB kinase-α were not inhibited by 10H2DA. On the other hand, reduction of LPS-induced IκB-ζ expression was discovered. Production of lipocalin-2 and granulocyte colony-stimulating factor (G-CSF), which is dependent on IκB-ζ, was also inhibited by 10H2DA, whereas that of IκB-ζ-independent cytokines/chemokines, such as IFN-β, murine monocyte chemotactic protein-1 (JE), macrophage inflammatory protein (MIP)-1α and MIP-2, was not. Together, 10H2DA specifically inhibited LPS-induced IκB-ζ expression, followed by inhibition of IκB-ζ-dependent gene production. These results suggest that 10H2DA is one of the components of royal jelly to show anti-inflammatory effects and could be a therapeutic drug candidate for inflammatory and autoimmune diseases associated with IκB-ζ and IL-6 production. |
| 巻・号 | 18(3) |
| ページ | 429-37 |
| 公開日 | 2012-6-1 |
| DOI | 10.1177/1753425911416022 |
| PII | 1753425911416022 |
| PMID | 21948282 |
| MeSH | Acute-Phase Proteins / genetics Acute-Phase Proteins / metabolism Animals Anti-Inflammatory Agents / chemistry Anti-Inflammatory Agents / pharmacology* Cell Line Down-Regulation Fatty Acids / chemistry Fatty Acids, Monounsaturated / chemistry Fatty Acids, Monounsaturated / pharmacology* Granulocyte Colony-Stimulating Factor / genetics Granulocyte Colony-Stimulating Factor / metabolism I-kappa B Kinase / genetics I-kappa B Kinase / metabolism* Interleukin-6 / genetics Interleukin-6 / metabolism* Lipocalin-2 Lipocalins / genetics Lipocalins / metabolism Lipopolysaccharides / immunology Lipopolysaccharides / metabolism Macrophage Activation / drug effects Macrophages / drug effects Macrophages / immunology* Mice Oncogene Proteins / genetics Oncogene Proteins / metabolism |
| IF | 2.298 |
| 引用数 | 14 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL MICROBIOLOGY IMMUNOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |