RRC ID 18685
著者 Ito R, Kanno H, Takahashi A, Matsumoto R, Kobayashi N, Yoshida T, Saito T.
タイトル Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53.
ジャーナル Protein Pept Lett
Abstract Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.
巻・号 17(5)
ページ 610-5
公開日 2010-5-1
DOI 10.2174/092986610791112639
PII 0110
PMID 20015022
MeSH Amino Acid Sequence Analysis of Variance Antigens, Polyomavirus Transforming / genetics Antigens, Polyomavirus Transforming / metabolism Binding Sites Bone Neoplasms / chemistry Bone Neoplasms / genetics Bone Neoplasms / metabolism* Cell Proliferation / drug effects Cell Survival / drug effects Humans Molecular Sequence Data Osteosarcoma / chemistry Osteosarcoma / genetics Osteosarcoma / metabolism* Peptides / genetics Peptides / metabolism Proto-Oncogene Proteins c-mdm2 / metabolism* Recombinant Fusion Proteins / chemistry Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Recombinant Fusion Proteins / pharmacology Signal Transduction Tumor Suppressor Protein p53 / chemistry Tumor Suppressor Protein p53 / genetics Tumor Suppressor Protein p53 / metabolism* Tumor Suppressor Protein p53 / pharmacology
IF 1.156
引用数 1
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 Saos-2(RCB0428)