論文 - 詳細
RRC ID | 18729 |
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著者 | Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. |
タイトル | Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression. |
ジャーナル | Immunol Lett |
Abstract |
The role of retinoblastoma protein-interacting zinc finger 1 (RIZ1) in receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast formation was examined in mouse RAW 264.7 macrophage-like cells. The expression of RIZ1 was significantly augmented by RANKL-treated cells. Silencing of RIZ1 with the siRNA significantly reduced the appearance of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells as osteoclasts in RANKL-treated cells. The expression of nuclear factor of activated T cell 1 (NFATc1) as the terminal transcription factor of osteoclast formation was prevented by RIZ1 siRNA. It was suggested that that RIZ1 might participate in RANKL-induced osteoclast formation through the regulation of NFATc1 expression. |
巻・号 | 131(2) |
ページ | 166-9 |
公開日 | 2010-7-8 |
DOI | 10.1016/j.imlet.2010.04.006 |
PII | S0165-2478(10)00123-9 |
PMID | 20417662 |
MeSH | Acid Phosphatase / biosynthesis Animals Antigens, Differentiation / biosynthesis Bone Resorption Cell Line Gene Expression Regulation Histone-Lysine N-Methyltransferase / genetics Histone-Lysine N-Methyltransferase / immunology Histone-Lysine N-Methyltransferase / metabolism* Isoenzymes / biosynthesis Macrophages / immunology Macrophages / metabolism* Macrophages / pathology Mice NFATC Transcription Factors / biosynthesis* NFATC Transcription Factors / genetics Neoplasms / metabolism* Neoplasms / pathology Neoplasms / physiopathology Osteoclasts / immunology Osteoclasts / metabolism* Osteoclasts / pathology RANK Ligand / metabolism RNA, Small Interfering / genetics Signal Transduction / genetics Signal Transduction / immunology Tartrate-Resistant Acid Phosphatase Transcription Factors / genetics Transcription Factors / immunology Transcription Factors / metabolism* |
IF | 3.276 |
引用数 | 9 |
WOS 分野 | IMMUNOLOGY |
リソース情報 | |
ヒト・動物細胞 | RAW 264(RCB0535) |