Reference - Detail
| RRC ID | 18743 |
|---|---|
| Author | Takadera T, Nakajima Y, Kanai Y. |
| Title | Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. |
| Journal | Cell Mol Neurobiol |
| Abstract |
The purpose of this study was to examine whether glycogen synthase kinase-3 (GSK-3) is involved in colchicine-induced cell death in PC12 cells by using GSK inhibitors. Colchicine increased apoptotic cell death with morphological changes characterized by cell shrinkage and nuclear condensation or fragmentation. GSK-3 inhibitors such as alsterpaullone, SB216763, and AR-A014418 prevented colchicine-induced cell death and caspase-3 activation. These results suggest that colchicine induces caspase-dependent apoptotic cell death and that GSK-3 activation is involved in cell death in PC12 cells. |
| Volume | 30(6) |
| Pages | 863-8 |
| Published | 2010-8-1 |
| DOI | 10.1007/s10571-010-9514-z |
| PMID | 20300959 |
| MeSH | Animals Apoptosis / drug effects* Caspase 3 / metabolism Colchicine / pharmacology* Dose-Response Relationship, Drug Enzyme Activation / drug effects Glycogen Synthase Kinase 3 / antagonists & inhibitors* Glycogen Synthase Kinase 3 / metabolism PC12 Cells Phosphorylation / drug effects Protective Agents / pharmacology Protein Kinase Inhibitors / pharmacology* Rats |
| IF | 3.606 |
| Times Cited | 1 |
| WOS Category | CELL BIOLOGY NEUROSCIENCES |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |