論文 - 詳細
| RRC ID | 19326 |
|---|---|
| 著者 | Kasugai C, Morikawa A, Naiki Y, Koide N, Komatsu T, Yoshida T, Yokochi T. |
| タイトル | Concanavalin A induces formation of osteoclast-like cells in RAW 264.7 mouse macrophage cells. |
| ジャーナル | Immunopharmacol Immunotoxicol |
| Abstract |
The effect of lectins on the formation of osteoclasts in RAW 264.7 mouse macrophage cells was examined. Concanavalin A (Con A) induced the formation of multinucleated giant cells (MGC) whereas pokeweed mitogen and phytohemagglutinin did not do it. Con A-induced MGC were positive for tartrate- resistant acid phosphatase (TRAP) activity, a histochemical marker of osteoclasts. Murine splenic macrophages differentiated into TRAP-positive and multinucleated cells in response to Con A whereas peritoneal macrophages did not. The culture supernatant from Con A-stimulated RAW 264.7 cells did not cause the MGC formation. The relationship between Con A-induced GMC formation and osteoclastgenesis is discussed. |
| 巻・号 | 31(1) |
| ページ | 103-7 |
| 公開日 | 2009-1-1 |
| DOI | 10.1080/08923970802438417 |
| PII | 908654651 |
| PMID | 19234958 |
| MeSH | Acid Phosphatase / metabolism Animals Cell Differentiation / drug effects* Cell Line Concanavalin A / pharmacology* Culture Media, Conditioned / pharmacology Giant Cells / cytology Giant Cells / metabolism Isoenzymes / metabolism Macrophages / cytology* Macrophages / drug effects Macrophages, Peritoneal / cytology Macrophages, Peritoneal / drug effects Mice Mitogen-Activated Protein Kinases / antagonists & inhibitors Osteoclasts / cytology* Osteoclasts / metabolism Phytohemagglutinins / pharmacology Pokeweed Mitogens / pharmacology Protein Kinase Inhibitors / pharmacology Signal Transduction / drug effects Tartrate-Resistant Acid Phosphatase |
| IF | 2.352 |
| 引用数 | 4 |
| WOS 分野 | PHARMACOLOGY & PHARMACY TOXICOLOGY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |