論文 - 詳細
| RRC ID | 19332 |
|---|---|
| 著者 | Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T. |
| タイトル | Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells. |
| ジャーナル | Anticancer Res |
| Abstract |
Bisphosphonates are strong inhibitors of osteoclastic bone resorption in both benign and malignant bone diseases. The nitrogen-containing bisphosphonates (N-BPs) have strong cytotoxicity via inhibition of protein prenylation in the mevalonate pathway, and also demonstrate direct cytostatic and proapoptotic effects on prostate cancer cells. We confirmed the usefulness of a co-culture system comprised of prostatic LNCaP cells, ST2 cells (mouse-derived osteoblasts) and MLC-6 cells (mouse-derived osteoclasts) in vitro. N-BPs (pamidronate and zoledronic acid) inhibited both androgen receptor transactivation and tumor cell proliferation by suppressing the activities of both osteoclasts and osteoblasts with low-dose exposure. This indirect inhibition of prostate cancer cells via bone cells could be beneficial in treating prostate cancer patients with bone metastases. |
| 巻・号 | 29(4) |
| ページ | 1089-94 |
| 公開日 | 2009-4-1 |
| PII | 29/4/1089 |
| PMID | 19414350 |
| MeSH | Animals Antineoplastic Agents / pharmacology Bone Density Conservation Agents / pharmacology Cell Proliferation / drug effects Coculture Techniques Diphosphonates / pharmacology* Humans Imidazoles / pharmacology* Luciferases / metabolism Male Mice Osteoblasts / cytology Osteoclasts / cytology Pamidronate Prostatic Neoplasms / drug therapy* Prostatic Neoplasms / metabolism Prostatic Neoplasms / pathology RNA, Messenger / genetics RNA, Messenger / metabolism Receptors, Androgen / genetics Receptors, Androgen / metabolism Reverse Transcriptase Polymerase Chain Reaction Transcriptional Activation Tumor Cells, Cultured Zoledronic Acid |
| IF | 1.994 |
| 引用数 | 5 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) MLC-6(RCB1536) |