Reference - Detail
| RRC ID | 19646 |
|---|---|
| Author | Haga A, Nagai H, Deyashiki Y. |
| Title | Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells. |
| Journal | Cancer Invest |
| Abstract |
Autotaxin (ATX) is an approximately 125-kDa transmembrane protein that is considered to be a tumor progression factor based on its lysophospholipase D activity. Here, we report that lysophosphatidic acid produced by ATX promotes the secretion of matrix metalloproteinase-3 (MMP3) from the human fibrosarcoma cell line HT-1080. The c-Jun N-terminal kinases (JNKs) and c-Jun of HT-1080 cells were rapidly phosphorylated after ATX treatment. A specific JNK inhibitor also exhibited this activation of signaling molecules and MMP3 expression. The present results suggest a novel function of ATX in promoting MMP3 production via the mitogen-activated protein kinase cascade, thereby stimulating tumor cell invasiveness. |
| Volume | 27(4) |
| Pages | 384-90 |
| Published | 2009-5-1 |
| DOI | 10.1080/07357900802491469 |
| PII | 908650320 |
| PMID | 19212832 |
| MeSH | Cell Line, Tumor Fibrosarcoma / enzymology* Fibrosarcoma / pathology Humans JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors JNK Mitogen-Activated Protein Kinases / metabolism* Lysophospholipids / metabolism MAP Kinase Signaling System* / drug effects Matrix Metalloproteinase 3 / genetics Matrix Metalloproteinase 3 / metabolism* Multienzyme Complexes / metabolism* Neoplasm Invasiveness Phosphodiesterase I / metabolism* Phosphoric Diester Hydrolases Phosphorylation Protein Kinase Inhibitors / pharmacology Pyrophosphatases / metabolism* RNA, Messenger / metabolism Recombinant Proteins / metabolism Up-Regulation |
| IF | 2.398 |
| Times Cited | 4 |
| WOS Category | ONCOLOGY |
| Resource | |
| Human and Animal Cells | HT1080(RCB1956) |