| RRC ID |
20945
|
| 著者 |
Imai H, Suzuki N, Ishimaru Y, Sakurai T, Yin L, Pan W, Abe K, Misaka T, Hirai H.
|
| タイトル |
Functional diversity of bitter taste receptor TAS2R16 in primates.
|
| ジャーナル |
Biol Lett
|
| Abstract |
In mammals, bitter taste is mediated by TAS2R genes, which belong to the large family of seven transmembrane G protein-coupled receptors. Because TAS2Rs are directly involved in the interaction between mammals and their dietary sources, it is likely that these genes evolved to reflect species-specific diets during mammalian evolution. Here, we investigated the sensitivities of TAS2R16s of various primates by using a cultured cell expression system, and found that the sensitivity of each primate species varied according to the ligand. Especially, the sensitivity of TAS2R16 of Japanese macaques to salicin was much lower than that of human TAS2R16, which was supported by behavioural tests. These results suggest the possibility that bitter-taste sensitivities evolved independently by replacing specific amino acid residues of TAS2Rs in different primate species to adapt to food items they use.
|
| 巻・号 |
8(4)
|
| ページ |
652-6
|
| 公開日 |
2012-8-23
|
| DOI |
10.1098/rsbl.2011.1251
|
| PII |
rsbl.2011.1251
|
| PMID |
22399783
|
| PMC |
PMC3391450
|
| MeSH |
Amino Acid Sequence
Animals
Behavior, Animal
Benzyl Alcohols / metabolism
Binding Sites
DNA / blood
Evolution, Molecular
Genes
Glucosides / metabolism
HEK293 Cells
Humans
Macaca / genetics*
Macaca / metabolism
Receptors, G-Protein-Coupled / genetics*
Receptors, G-Protein-Coupled / metabolism
Species Specificity
Taste / genetics*
Taste Perception
Transfection
|
| IF |
2.869
|
| 引用数 |
19
|
|
WOS 分野
|
BIOLOGY
ECOLOGY
EVOLUTIONARY BIOLOGY
|
| リソース情報 |
| ニホンザル |
|
