RRC ID |
21785
|
著者 |
Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z, Ohtsubo M, Honda H.
|
タイトル |
CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo.
|
ジャーナル |
FEBS Lett
|
Abstract |
CIZ1 is a nuclear protein involved in DNA replication and is also implicated in human diseases including cancers. To gain an insight into its function in vivo, we generated mice lacking Ciz1. Ciz1-deficient (Ciz1(-/-)) mice grew without any obvious abnormalities, and Ciz1(-/-) mouse embryonic fibroblasts (MEFs) did not show any defects in cell cycle status, cell growth, and DNA damage response. However, Ciz1(-/-) MEFs were sensitive to hydroxyurea-mediated replication stress and susceptible to oncogene-induced cellular transformation. In addition, Ciz1(-/-) mice developed various types of leukemias by retroviral insertional mutagenesis. These results indicate that CIZ1 functions as a tumor suppressor in vivo.
|
巻・号 |
587(10)
|
ページ |
1529-35
|
公開日 |
2013-5-21
|
DOI |
10.1016/j.febslet.2013.03.034
|
PII |
S0014-5793(13)00263-9
|
PMID |
23583447
|
MeSH |
Animals
Ataxia Telangiectasia Mutated Proteins
Cell Cycle / genetics
Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism
Cell Proliferation
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p21 / metabolism
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Embryo, Mammalian / cytology
Fibroblasts / metabolism
Fibroblasts / physiology
Mice
Mice, Knockout
Models, Biological
Nuclear Proteins / genetics
Nuclear Proteins / metabolism
Nuclear Proteins / physiology*
Protein Binding
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Tumor Suppressor Proteins* / genetics
Tumor Suppressor Proteins* / metabolism
Tumor Suppressor Proteins* / physiology
|
IF |
3.057
|
引用数 |
13
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
実験動物マウス |
RBRC01828 |