RRC ID 21915
著者 Homman-Ludiye J, Bourne JA.
タイトル The guidance molecule Semaphorin3A is differentially involved in the arealization of the mouse and primate neocortex.
ジャーナル Cereb Cortex
Abstract The visual cortex is organized into discrete domains characterized by their specific function, connectivity, chemoarchitecture, and cytoarchitecture. Gradients of transcription factors across the anteroposterior and mediolateral axes of the neocortex have previously been demonstrated to specify the main sensory regions. However, they do not account for the establishment of multiple areas in the primate visual cortex, which occupies approximately 50% of the neocortical surface. We demonstrate that the guidance molecule Semaphorin3A (Sema3A) is initially secreted in the cortical plate of the embryonic marmoset monkey and acts as an intrinsic cue to control the migration of subpopulations of neuronal progenitors and projection neurons expressing the receptor Neuropilin 1 (Npn1). During the first 2 postnatal weeks, Sema3A expression becomes primarily associated with ventral visual cortical areas, leading to the specific migration of Npn1+ neurons in the late maturing visual areas. In the mouse, Sema3A distribution is not arealized, but Npn1 expression becomes restricted to the posterior neocortex at embryonic day 16.5. The selective reduction in the striate cortex we observe in Sema3A-/- animals potentially results from the differential distribution of Npn1+ cells. Therefore, the Sema3A/Npn1 pathway participates to the parcellation of the visual neocortex in both the mouse and the marmoset, however, through different regulatory processes.
巻・号 24(11)
ページ 2884-98
公開日 2014-11-1
DOI 10.1093/cercor/bht141
PII bht141
PMID 23709645
MeSH Age Factors Animals Animals, Newborn Callithrix Embryo, Mammalian Female Gene Expression Regulation, Developmental / genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Neocortex / cytology* Neocortex / physiology* Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Neurons / metabolism* Neuropilin-1 / genetics Neuropilin-1 / metabolism RNA, Messenger / metabolism Semaphorin-3A / genetics Semaphorin-3A / metabolism* Transcription Factors / genetics Transcription Factors / metabolism
IF 5.043
引用数 9
WOS 分野 NEUROSCIENCES
リソース情報
実験動物マウス RBRC01105