Reference - Detail
| RRC ID | 21951 |
|---|---|
| Author | Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y. |
| Title | Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. |
| Journal | EMBO Rep |
| Abstract |
Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human intestinal colonizer Pseudomonas aeruginosa synergizes with the Ras1V12 oncogene to induce basal invasion and dissemination of hindgut cells to distant sites. Cross-talk between infection and dissemination requires sustained activation by the bacteria of the Imd-dTab2-dTak1 innate immune pathway, which converges with Ras1V12 signalling on JNK pathway activation, culminating in extracellular matrix degradation. Hindgut, but not midgut, cells are amenable to this cooperative dissemination, which is progressive and genetically and pharmacologically inhibitable. Thus, Drosophila hindgut provides a valuable system for the study of intestinal malignancies. |
| Volume | 13(6) |
| Pages | 569-76 |
| Published | 2012-6-1 |
| DOI | 10.1038/embor.2012.44 |
| PII | embor201244 |
| PMID | 22498775 |
| PMC | PMC3367237 |
| MeSH | Amino Acid Substitution Animals Cell Movement* Colorectal Neoplasms Disease Models, Animal Drosophila / cytology Drosophila / immunology* Drosophila / microbiology Drosophila Proteins / genetics Drosophila Proteins / metabolism* Epithelial Cells / metabolism Epithelial Cells / microbiology Epithelial Cells / physiology Gastrointestinal Tract / cytology Gastrointestinal Tract / immunology* Gastrointestinal Tract / microbiology Host-Pathogen Interactions Immunity, Innate JNK Mitogen-Activated Protein Kinases / metabolism Oncogene Proteins / genetics Oncogene Proteins / metabolism Pseudomonas aeruginosa / physiology* Signal Transduction ras Proteins / genetics ras Proteins / metabolism* |
| IF | 7.497 |
| Times Cited | 33 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Drosophila | 1388R-1 1388R-2 7486R-1 5680R-1 5680R-2 2275R-1 2275R-2 5576R-1 5576R-2 |