論文 - 詳細
| RRC ID | 21955 |
|---|---|
| 著者 | Ma X, Huang J, Yang L, Yang Y, Li W, Xue L. |
| タイトル | NOPO modulates Egr-induced JNK-independent cell death in Drosophila. |
| ジャーナル | Cell Res |
| Abstract |
Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive. To further delineate the Egr-triggered cell death pathway, we performed a genetic screen to identify dominant modifiers of the Egr-induced cell death phenotype. Here we report that Egr elicits a caspase-mediated cell death pathway independent of JNK signaling. Furthermore, we show NOPO, the Drosophila ortholog of TRIP (TRAF interacting protein) encoding an E3 ubiquitin ligase, modulates Egr-induced Caspase-mediated cell death through transcriptional activation of pro-apoptotic genes reaper and hid. Finally, we found Bendless and dUEV1a, an ubiquitin-conjugating E2 enzyme complex, regulates NOPO-triggered cell death. Our results indicate that the Ben-dUEV1a complex constitutes a molecular switch that bifurcates the Egr-induced cell death signaling into two pathways mediated by JNK and caspases respectively. |
| 巻・号 | 22(2) |
| ページ | 425-31 |
| 公開日 | 2012-2-1 |
| DOI | 10.1038/cr.2011.135 |
| PII | cr2011135 |
| PMID | 21844890 |
| PMC | PMC3271591 |
| MeSH | Animals Apoptosis* Caspases / metabolism Drosophila / cytology Drosophila / enzymology Drosophila Proteins / metabolism* JNK Mitogen-Activated Protein Kinases / metabolism* Membrane Proteins / metabolism* Neuropeptides / metabolism Signal Transduction Ubiquitin-Conjugating Enzymes / metabolism Ubiquitin-Protein Ligases / metabolism* |
| IF | 20.507 |
| 引用数 | 40 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
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| ショウジョウバエ | |