| RRC ID |
22013
|
| Author |
Takeishi A, Kuranaga E, Tonoki A, Misaki K, Yonemura S, Kanuka H, Miura M.
|
| Title |
Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila.
|
| Journal |
Cell Rep
|
| Abstract |
Effective defense responses involve the entire organism. To maintain body homeostasis after tissue damage, a systemic wound response is induced in which the response of each tissue is tightly orchestrated to avoid incomplete recovery or an excessive, damaging response. Here, we provide evidence that in the systemic response to wounding, an apoptotic caspase pathway is activated downstream of reactive oxygen species in the midgut enterocytes (ECs), cells distant from the wound site, in Drosophila. We show that a caspase-pathway mutant has defects in homeostatic gut cell renewal and that inhibiting caspase activity in fly ECs results in the production of systemic lethal factors after wounding. Our results indicate that wounding remotely controls caspase activity in ECs, which activates the tissue stem cell regeneration pathway in the gut to dampen the dangerous systemic wound reaction.
|
| Volume |
3(3)
|
| Pages |
919-30
|
| Published |
2013-3-28
|
| DOI |
10.1016/j.celrep.2013.02.022
|
| PII |
S2211-1247(13)00098-3
|
| PMID |
23523355
|
| MeSH |
Animals
Apoptosis*
Caspases / genetics
Caspases / metabolism
Cell Proliferation*
Drosophila / metabolism*
Drosophila / physiology
Enterocytes / metabolism*
Enterocytes / physiology
Homeostasis
Intestines / injuries
Mutation
Reactive Oxygen Species / metabolism
Wound Healing*
|
| IF |
8.109
|
| Times Cited |
31
|
|
WOS Category
|
CELL BIOLOGY
|
| Resource |
| Drosophila |
|
