論文 - 詳細
| RRC ID | 22793 |
|---|---|
| 著者 | Ishii K, Adachi T, Hamamoto H, Oonishi T, Kamimura M, Imamura K, Sekimizu K. |
| タイトル | Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in the silkworm Bombyx mori. |
| ジャーナル | Dev Comp Immunol |
| Abstract |
Insect cytokine paralytic peptide (PP) upregulates the expression of immune-related genes and contributes to host defense in the silkworm Bombyx mori. The present findings demonstrated that PP promotes nitric oxide (NO) production and induces the expression of NO synthase. A pharmacologic NO synthase inhibitor suppressed the PP-dependent (i) induction of immune-related genes, (ii) activation of p38 mitogen-activated protein kinase, and (iii) killing delay of silkworm larvae by Staphylococcus aureus. The upstream mechanism of NO synthesis in insect immunity has been unknown, and the present results suggest for the first time that an insect cytokine induces NO and contributes to self-defense. |
| 巻・号 | 39(3) |
| ページ | 147-53 |
| 公開日 | 2013-3-1 |
| DOI | 10.1016/j.dci.2012.10.014 |
| PII | S0145-305X(12)00239-X |
| PMID | 23178406 |
| MeSH | Animals Apoptosis / drug effects Bombyx / immunology* Bombyx / microbiology Cells, Cultured Cytokines / chemical synthesis Cytokines / immunology* Immunity, Innate / drug effects Insect Proteins / genetics Insect Proteins / metabolism* Muscle Contraction / drug effects NG-Nitroarginine Methyl Ester / pharmacology Neuropeptides / administration & dosage Neuropeptides / chemical synthesis Neuropeptides / immunology* Nitric Oxide / metabolism* Nitric Oxide Synthase / antagonists & inhibitors Nitric Oxide Synthase / genetics Nitric Oxide Synthase / metabolism* Paralysis / etiology Paralysis / prevention & control Signal Transduction / drug effects Staphylococcus aureus / immunology* Up-Regulation / drug effects p38 Mitogen-Activated Protein Kinases / metabolism |
| IF | 3.192 |
| 引用数 | 18 |
| WOS 分野 | ZOOLOGY IMMUNOLOGY |
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