RRC ID 2443
Author Aizawa H, Goto M, Sato T, Okamoto H.
Title Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures.
Journal Dev. Cell
Abstract The habenular neurons on both sides of the zebrafish diencephalon show an asymmetric (laterotopic) axonal projection pattern into the interpeduncular nucleus. We previously revealed that the habenula could be subdivided into medial and lateral subnuclei, and a prominent left-right difference in the size ratio of these subnuclei accounts for the asymmetry in its neural connectivity. In the present study, birth date analysis showed that neural precursors for the lateral subnuclei were born at earlier stages than those for the medial subnuclei. More neurons for the early-born lateral subnuclei were generated on the left side, while more neurons for the late-born medial subnuclei were generated on the right side. Genetic hyperactivation and repression of Notch signaling revealed that differential timing determines both specificity and asymmetry in the neurogenesis of neural precursors for the habenular subnuclei.
Volume 12(1)
Pages 87-98
Published 2007-1
DOI 10.1016/j.devcel.2006.10.004
PII S1534-5807(06)00456-4
PMID 17199043
MeSH Animals Body Patterning / physiology* Cation Transport Proteins Cell Differentiation* Embryo, Nonmammalian / anatomy & histology Embryo, Nonmammalian / cytology Embryo, Nonmammalian / embryology Gene Expression Regulation, Developmental Habenula / anatomy & histology Habenula / cytology* Habenula / embryology* Models, Neurological Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Neurons / cytology* RNA, Messenger / genetics RNA, Messenger / metabolism Receptor Protein-Tyrosine Kinases / genetics Receptor Protein-Tyrosine Kinases / metabolism Receptors, Notch / metabolism Signal Transduction Time Factors Zebrafish / anatomy & histology* Zebrafish / embryology* Zebrafish Proteins / genetics Zebrafish Proteins / metabolism
IF 9.19
Times Cited 71
WOS Category DEVELOPMENTAL BIOLOGY CELL BIOLOGY
Resource
Zebrafish RIKEN WT (RW)