| RRC ID |
2443
|
| 著者 |
Aizawa H, Goto M, Sato T, Okamoto H.
|
| タイトル |
Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures.
|
| ジャーナル |
Dev Cell
|
| Abstract |
The habenular neurons on both sides of the zebrafish diencephalon show an asymmetric (laterotopic) axonal projection pattern into the interpeduncular nucleus. We previously revealed that the habenula could be subdivided into medial and lateral subnuclei, and a prominent left-right difference in the size ratio of these subnuclei accounts for the asymmetry in its neural connectivity. In the present study, birth date analysis showed that neural precursors for the lateral subnuclei were born at earlier stages than those for the medial subnuclei. More neurons for the early-born lateral subnuclei were generated on the left side, while more neurons for the late-born medial subnuclei were generated on the right side. Genetic hyperactivation and repression of Notch signaling revealed that differential timing determines both specificity and asymmetry in the neurogenesis of neural precursors for the habenular subnuclei.
|
| 巻・号 |
12(1)
|
| ページ |
87-98
|
| 公開日 |
2007-1-1
|
| DOI |
10.1016/j.devcel.2006.10.004
|
| PII |
S1534-5807(06)00456-4
|
| PMID |
17199043
|
| MeSH |
Animals
Body Patterning / physiology*
Cation Transport Proteins
Cell Differentiation*
Embryo, Nonmammalian / anatomy & histology
Embryo, Nonmammalian / cytology
Embryo, Nonmammalian / embryology
Gene Expression Regulation, Developmental
Habenula / anatomy & histology
Habenula / cytology*
Habenula / embryology*
Models, Neurological
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism
Neurons / cytology*
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptor Protein-Tyrosine Kinases / genetics
Receptor Protein-Tyrosine Kinases / metabolism
Receptors, Notch / metabolism
Signal Transduction
Time Factors
Zebrafish / anatomy & histology*
Zebrafish / embryology*
Zebrafish Proteins / genetics
Zebrafish Proteins / metabolism
|
| IF |
10.092
|
| 引用数 |
87
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ゼブラフィッシュ |
RIKEN WT (RW) |
