論文 - 詳細
| RRC ID | 2480 |
|---|---|
| 著者 | Kerstetter AE, Azodi E, Marrs JA, Liu Q. |
| タイトル | Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish. |
| ジャーナル | Dev Dyn |
| Abstract |
Cadherins are cell surface molecules that mediate cell-cell adhesion through homophilic interactions. Cadherin-2 (also called N-cadherin), a member of classic cadherin subfamily, has been shown to play important roles in development of a variety of tissues and organs, including the nervous system. We recently reported that cadherin-2 was strongly expressed by the majority of cranial ganglia and lateral line system of developing zebrafish. To gain insight into cadherin-2 role in the formation of these structures, we have used several markers to analyze zebrafish embryos injected with a specific cadherin-2 antisense morpholino oligonucleotide (cdh2MO). We find that development of several cranial ganglia, including the trigeminal, facial, and vagal ganglia, and the lateral line ganglia and neuromasts of the cdh2MO-injected embryos are severely disrupted. These phenotypes were confirmed by analyzing a cadherin-2 mutant, glass onion. Our results suggest that cadherin-2 function is crucial for the normal formation of the zebrafish lateral line system and a subset of cranial ganglia. |
| 巻・号 | 230(1) |
| ページ | 137-43 |
| 公開日 | 2004-5-1 |
| DOI | 10.1002/dvdy.20021 |
| PMID | 15108318 |
| MeSH | Animals Basal Ganglia / embryology Brain / embryology Cadherins / biosynthesis Cell Adhesion Cell Adhesion Molecules / biosynthesis* Cell Membrane / metabolism Gene Expression Regulation, Developmental* Immunohistochemistry In Situ Hybridization Models, Anatomic Neurons / metabolism Oligonucleotides, Antisense / metabolism Zebrafish Zebrafish Proteins / chemistry |
| IF | 3.275 |
| 引用数 | 43 |
| WOS 分野 | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
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| 各媒体での言及数の合計 | 0 |
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