| RRC ID |
275
|
| Author |
Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M.
|
| Title |
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway.
|
| Journal |
EMBO J
|
| Abstract |
Drosophila provides a powerful genetic model for studying the in vivo regulation of cell death. In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate tumor necrosis factor (TNF) superfamily ligand that can induce cell death. Eiger is a type II transmembrane protein with a C-terminal TNF homology domain. It is predominantly expressed in the nervous system. Genetic evidence shows that Eiger induces cell death by activating the Drosophila JNK pathway. Although this cell death process is blocked by Drosophila inhibitor-of-apoptosis protein 1 (DIAP1), it does not require caspase activity. We also show genetically that Eiger is a physiological ligand for the Drosophila JNK pathway. Our findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling.
|
| Volume |
21(12)
|
| Pages |
3009-18
|
| Published |
2002-6-17
|
| DOI |
10.1093/emboj/cdf306
|
| PMID |
12065414
|
| PMC |
PMC126061
|
| MeSH |
Amino Acid Sequence
Animals
Apoptosis / physiology
Drosophila Proteins / chemistry
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster / anatomy & histology
Drosophila melanogaster / genetics
Drosophila melanogaster / growth & development
Drosophila melanogaster / physiology*
Embryo, Nonmammalian / anatomy & histology
Embryo, Nonmammalian / physiology
Genes, Insect
In Situ Hybridization
Inhibitor of Apoptosis Proteins
Insect Proteins / physiology
JNK Mitogen-Activated Protein Kinases
Ligands
MAP Kinase Signaling System / physiology*
Membrane Proteins / chemistry
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Mitogen-Activated Protein Kinases / metabolism*
Molecular Sequence Data
Multigene Family
Peptides / genetics
Peptides / metabolism
Phenotype
Photoreceptor Cells, Invertebrate / growth & development
Proteins*
Sequence Alignment
Tumor Necrosis Factor-alpha / genetics
Tumor Necrosis Factor-alpha / metabolism*
|
| IF |
9.889
|
| Times Cited |
312
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Drosophila |
DGRC#119561
DGRC#119562
DGRC#119572 |
