| RRC ID |
276
|
| Author |
Inaki M, Kojima T, Ueda R, Saigo K.
|
| Title |
Requirements of high levels of Hedgehog signaling activity for medial-region cell fate determination in Drosophila legs: identification of pxb, a putative Hedgehog signaling attenuator gene repressed along the anterior-posterior compartment boundary.
|
| Journal |
Mech Dev
|
| Abstract |
We show that high levels of Hedgehog signaling activity are essential for medial-region patterning in Drosophila legs. In mid-to-late third instar leg discs, high levels of Hedgehog signals repress the transcription of pxb, a newly identified gene encoding a transmembrane protein expressed specifically in the anterior compartment. Misexpression experiments indicate that Pxb may serve as a Hedgehog signaling attenuator capable of acting prior to Hedgehog-Patched interactions, suggesting that Hedgehog signaling in leg discs includes a pxb-repression-mediated positive feedback loop. RNA interference and clonal analysis show that neither Wingless nor Decapentaplegic signaling is required for pxb repression but high levels of Wingless signaling activity are essential for patterning in the leg ventral medial region.
|
| Volume |
116(1-2)
|
| Pages |
3-18
|
| Published |
2002-8-1
|
| DOI |
10.1016/s0925-4773(02)00119-3
|
| PII |
S0925477302001193
|
| PMID |
12128201
|
| MeSH |
Amino Acid Sequence
Animals
Body Patterning / genetics
Drosophila / genetics*
Drosophila / growth & development*
Drosophila / metabolism
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism
Enhancer Elements, Genetic
Feedback
Gene Expression Regulation, Developmental
Genes, Insect*
Genes, Reporter
Hedgehog Proteins
Lac Operon
Leg
Membrane Proteins / genetics
Membrane Proteins / metabolism
Models, Biological
Molecular Sequence Data
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / metabolism
RNA Interference
Receptors, Cell Surface
Signal Transduction
Wnt1 Protein
|
| IF |
2.126
|
| Times Cited |
14
|
|
WOS Category
|
DEVELOPMENTAL BIOLOGY
|
| Resource |
| Drosophila |
4889R-3
4889R-4
9885R-1
9885R-2 |
