論文 - 詳細
| RRC ID | 278 |
|---|---|
| 著者 | Kanda H, Igaki T, Kanuka H, Yagi T, Miura M. |
| タイトル | Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. |
| ジャーナル | J Biol Chem |
| Abstract |
We identified Wengen, the first member of the Drosophila tumor necrosis factor receptor (TNFR) superfamily. Wengen is a type III membrane protein with conserved cysteine-rich residues (TNFR homology domain) in the extracellular domain, a hallmark of the TNFR superfamily. wengen mRNA is expressed at all stages of Drosophila development. The small-eye phenotype caused by an eye-specific overexpression of a Drosophila TNF superfamily ligand, Eiger, was dramatically suppressed by down-regulation of Wengen using RNA interference. In addition, Wengen and Eiger physically interacted with each other through their TNFR homology domain and TNF homology domain, respectively. These results suggest that Wengen can act as a component of a functional receptor for Eiger. Our identification of Wengen and further genetic analysis should provide increased understanding of the evolutionarily conserved roles of TNF/TNFR superfamily proteins in normal development, as well as in some pathophysiological conditions. |
| 巻・号 | 277(32) |
| ページ | 28372-5 |
| 公開日 | 2002-8-9 |
| DOI | 10.1074/jbc.C200324200 |
| PII | S0021-9258(20)70226-7 |
| PMID | 12084706 |
| MeSH | Amino Acid Sequence Animals Animals, Genetically Modified Blotting, Western Cloning, Molecular DNA, Complementary / metabolism Down-Regulation Drosophila / metabolism* Drosophila Proteins / physiology* Electrophoresis, Polyacrylamide Gel Ligands Membrane Proteins / physiology* Microscopy, Fluorescence Models, Genetic Molecular Sequence Data Phenotype Precipitin Tests Protein Structure, Tertiary Receptors, Tumor Necrosis Factor / physiology* Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Signal Transduction Transfection Tumor Necrosis Factor-alpha / metabolism* |
| IF | 4.238 |
| 引用数 | 120 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119564 DGRC#119565 DGRC#119566 |