Reference - Detail
RRC ID | 283 |
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Author | Ohshiro T, Emori Y, Saigo K. |
Title | Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. |
Journal | Mech Dev |
Abstract |
Spatially and temporally regulated activity of Branchless/Breathless signaling is essential for trachea development in Drosophila. Early ubiquitous breathless (btl) expression is controlled by binding of Trachealess/Tango heterodimers to the btl minimum enhancer. Branchless/Breathless signaling includes a Sprouty-dependent negative feedback loop. We show that late btl expression is a target of Branchless/Breathless signaling and hence, Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells. Branchless/Breathless signaling activates MAP-kinase, which in turn, activates late btl expression and destabilizes Anterior-open, a repressor for late btl expression. Biochemical and genetic analysis indicated that the minimum btl enhancer includes binding sites of Anterior-open. |
Volume | 114(1-2) |
Pages | 3-11 |
Published | 2002-6-1 |
DOI | 10.1016/s0925-4773(02)00042-4 |
PII | S0925477302000424 |
PMID | 12175485 |
MeSH | Animals Base Sequence Drosophila / embryology* Drosophila Proteins / metabolism Eye Proteins / metabolism Gene Expression Regulation, Developmental* Immunohistochemistry Ligands MAP Kinase Signaling System Models, Genetic Molecular Sequence Data Mutagenesis Plasmids / metabolism Polymerase Chain Reaction Protein-Tyrosine Kinases* RNA / metabolism Receptors, Fibroblast Growth Factor / metabolism* Repressor Proteins / metabolism Signal Transduction Trachea / embryology* Transcription, Genetic |
IF | 2.126 |
Times Cited | 43 |
WOS Category | DEVELOPMENTAL BIOLOGY |
Resource | |
Drosophila |