RRC ID 28448
Author Inuzuka H, Miyatani S, Takeichi M.
Title R-cadherin: a novel Ca(2+)-dependent cell-cell adhesion molecule expressed in the retina.
Journal Neuron
Abstract cDNAs encoding a novel member of the cadherin cell adhesion receptor family were cloned. This cadherin is expressed in the retina of the chicken and is termed R-cadherin. It is similar to other cadherins in its primary structure, but most resembles N-cadherin, showing 74% amino acid identity. Cells expressing R-cadherin can adhere to those expressing N-cadherin when mixed, but they form homotypic clusters within their chimeric aggregates. In the development of the neural retina, R-cadherin begins to be expressed around embryonic day 8 in both neuronal and glial cells, and this expression continues up to the hatching stage. The pattern of the expression of R-cadherin was different from that of N-cadherin, suggesting distinctive roles in retinal morphogenesis.
Volume 7(1)
Pages 69-79
Published 1991-7
PII 0896-6273(91)90075-B
PMID 1712604
MeSH Amino Acid Sequence Animals Cadherins / genetics Cadherins / metabolism Cadherins / physiology* Cell Adhesion Molecules / metabolism Cell Adhesion Molecules / physiology* Chick Embryo DNA / metabolism Fluorescent Antibody Technique Molecular Sequence Data Retina / metabolism* Staining and Labeling
IF 14.319
Times Cited 193
DNA material Chicken R-cadherin full length cDNA (RDB01188).