| RRC ID |
28666
|
| 著者 |
Pancer Z, Saha NR, Kasamatsu J, Suzuki T, Amemiya CT, Kasahara M, Cooper MD.
|
| タイトル |
Variable lymphocyte receptors in hagfish.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
A previously uncharacterized type of variable lymphocyte receptors (VLR) was identified recently in the Sea lamprey. This jawless vertebrate generates an extensive VLR repertoire through differential insertion of neighboring diverse leucine-rich repeat (LRR) cassettes into an incomplete germ-line VLR gene. We report here VLR homologs from two additional lamprey species and the presence of two types of VLR genes in hagfish, the only other order of contemporary jawless vertebrates. As in the Sea lamprey, the incomplete hagfish germ-line VLR-A and -B genes are modified in lymphocyte-like cells to generate highly diverse repertoires of VLR-A and -B proteins via a presently undetermined mechanism. This jawless-fish mode of VLR diversification starkly contrasts with the rearrangement of Ig V(D)J gene segments used by all jawed vertebrates to produce diverse repertoires of T and B lymphocyte antigen receptors. The development of two very different strategies for receptor diversification at the dawn of vertebrate evolution approximately 500 million years ago attests to the fitness value of a lymphocyte-based system of anticipatory immunity.
|
| 巻・号 |
102(26)
|
| ページ |
9224-9
|
| 公開日 |
2005-6-28
|
| DOI |
10.1073/pnas.0503792102
|
| PII |
0503792102
|
| PMID |
15964979
|
| PMC |
PMC1166628
|
| MeSH |
Amino Acid Motifs
Amino Acid Sequence
Animals
Chromosomes, Artificial, Bacterial
Cloning, Molecular
Databases, Genetic
Evolution, Molecular
Gene Library
Hagfishes
Leucine / chemistry
Lymphocytes / metabolism*
Models, Genetic
Molecular Sequence Data
Phylogeny
Protein Structure, Tertiary
Receptors, Antigen / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
VDJ Recombinases / metabolism
|
| IF |
9.412
|
| 引用数 |
152
|
|
WOS 分野
|
IMMUNOLOGY
|
| リソース情報 |
| 遺伝子材料 |
VLRB.61 (RDB06725) |
