RRC ID 28877
著者 Lenz S, Karsten P, Schulz JB, Voigt A.
タイトル Drosophila as a screening tool to study human neurodegenerative diseases.
ジャーナル J Neurochem
Abstract In an aging society, research involving neurodegenerative disorders is of paramount importance. Over the past few years, research on Alzheimer's and Parkinson's diseases has made tremendous progress. Experimental studies, however, rely mostly on transgenic animal models, preferentially using mice. Although experiments on mice have enormous advantages, they also have some inherent limitations, some of which can be overcome by the use of Drosophila melanogaster as an experimental animal. Among the major advantages of using the fly is its small genome, which can also be modified very easily. The fact that its genome lends itself to diverse alterations (e. g. mutagenesis, transposons) has made the fly a useful organism to perform large-scale and genome-wide screening approaches. This has opened up an entirely new field of experimental research aiming to elucidate genetic interactions and screen for modifiers of disease processes in vivo. Here, we provide a brief overview of how flies can be used to analyze molecular mechanisms underlying human neurodegenerative diseases.
巻・号 127(4)
ページ 453-60
公開日 2013-11-1
DOI 10.1111/jnc.12446
PMID 24028575
MeSH Animals Disease Models, Animal* Drosophila / cytology Drosophila / genetics* Drosophila / metabolism Drosophila Proteins / genetics* Drosophila Proteins / metabolism Genes, Insect* Humans Neurodegenerative Diseases / genetics* Neurodegenerative Diseases / metabolism Neurodegenerative Diseases / pathology Photoreceptor Cells, Invertebrate / cytology Photoreceptor Cells, Invertebrate / metabolism
IF 4.066
引用数 41
WOS 分野 NEUROSCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY
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