| RRC ID |
28894
|
| 著者 |
Fan Y, Wang S, Hernandez J, Yenigun VB, Hertlein G, Fogarty CE, Lindblad JL, Bergmann A.
|
| タイトル |
Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila.
|
| ジャーナル |
PLoS Genet
|
| Abstract |
Recent work in several model organisms has revealed that apoptotic cells are able to stimulate neighboring surviving cells to undergo additional proliferation, a phenomenon termed apoptosis-induced proliferation. This process depends critically on apoptotic caspases such as Dronc, the Caspase-9 ortholog in Drosophila, and may have important implications for tumorigenesis. While it is known that Dronc can induce the activity of Jun N-terminal kinase (JNK) for apoptosis-induced proliferation, the mechanistic details of this activation are largely unknown. It is also controversial if JNK activity occurs in dying or in surviving cells. Signaling molecules of the Wnt and BMP families have been implicated in apoptosis-induced proliferation, but it is unclear if they are the only ones. To address these questions, we have developed an efficient assay for screening and identification of genes that regulate or mediate apoptosis-induced proliferation. We have identified a subset of genes acting upstream of JNK activity including Rho1. We also demonstrate that JNK activation occurs both in apoptotic cells as well as in neighboring surviving cells. In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling. These data underscore the importance of genetic screening and promise an improved understanding of the mechanisms of apoptosis-induced proliferation.
|
| 巻・号 |
10(1)
|
| ページ |
e1004131
|
| 公開日 |
2014-1-1
|
| DOI |
10.1371/journal.pgen.1004131
|
| PII |
PGENETICS-D-12-01255
|
| PMID |
24497843
|
| PMC |
PMC3907308
|
| MeSH |
Animals
Apoptosis / genetics*
Carcinogenesis / genetics*
Caspases
Cell Proliferation
Drosophila Proteins / genetics*
Drosophila Proteins / isolation & purification
Drosophila Proteins / metabolism
Drosophila melanogaster
ErbB Receptors / genetics*
ErbB Receptors / metabolism
Humans
MAP Kinase Kinase 4 / genetics*
Models, Genetic
Neoplasms / genetics
Neoplasms / pathology
Receptors, Invertebrate Peptide / genetics*
Receptors, Invertebrate Peptide / metabolism
Regeneration / genetics
Wnt Signaling Pathway
rho GTP-Binding Proteins / genetics*
rho GTP-Binding Proteins / isolation & purification
|
| IF |
5.175
|
| 引用数 |
50
|
|
WOS 分野
|
GENETICS & HEREDITY
|
| リソース情報 |
| ショウジョウバエ |
|
