論文 - 詳細
| RRC ID | 29045 |
|---|---|
| 著者 | Wang N, Wu WI, De Lozanne A. |
| タイトル | BEACH family of proteins: phylogenetic and functional analysis of six Dictyostelium BEACH proteins. |
| ジャーナル | J Cell Biochem |
| Abstract |
The beige and Chediak-Higashi syndrome (BEACH)-domain containing proteins constitute a new family of proteins found in all eukaryotes. The function of these proteins, which include the Chediak-Higashi syndrome (CHS) protein, Neurobeachin, LvsA, and FAN, is still poorly understood. To understand the diversity of this novel protein family, we analyzed a large array of BEACH-family protein sequences from several organisms. Comparison of all these sequences suggests that they can be classified into five distinct groups that may represent five distinct functional classes. In Dictyostelium we identified six proteins in this family, named LvsA-F, that belong to four of those classes. To test the function of these proteins in Dictyostelium we created disruption mutants in each of the lvs genes. Phenotypic analyses of these mutants indicate that LvsA is required for cytokinesis and osmoregulation and LvsB functions in lysosomal traffic. The LvsC-F proteins are not required for these or other processes such as growth and development. These results strongly support the concept that BEACH proteins from different classes have distinct cellular functions. Having six distinct BEACH proteins, Dictyostelium should be an excellent model system to dissect the molecular function of this interesting family of proteins. |
| 巻・号 | 86(3) |
| ページ | 561-70 |
| 公開日 | 2002-1-1 |
| DOI | 10.1002/jcb.10254 |
| PMID | 12210762 |
| MeSH | Amino Acid Sequence Animals Cell Division Databases, Protein Dictyostelium / cytology Dictyostelium / genetics Dictyostelium / growth & development Dictyostelium / metabolism* Lysosomes / metabolism Molecular Sequence Data Mutation Phylogeny* Protein Structure, Tertiary Protein Transport Proteins / chemistry Proteins / genetics Proteins / metabolism Protozoan Proteins / chemistry* Protozoan Proteins / genetics Protozoan Proteins / metabolism* Sequence Alignment Sequence Homology, Amino Acid Water-Electrolyte Balance |
| IF | 4.237 |
| 引用数 | 32 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 細胞性粘菌 | S90284 |