論文 - 詳細
| RRC ID | 29701 |
|---|---|
| 著者 | Sato A, Sokabe T, Kashio M, Yasukochi Y, Tominaga M, Shiomi K. |
| タイトル | Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
In the bivoltine strain of the silkworm, Bombyx mori, embryonic diapause is induced transgenerationally as a maternal effect. Progeny diapause is determined by the environmental temperature during embryonic development of the mother; however, its molecular mechanisms are largely unknown. Here, we show that the Bombyx TRPA1 ortholog (BmTrpA1) acts as a thermosensitive transient receptor potential (TRP) channel that is activated at temperatures above ∼ 21 °C and affects the induction of diapause in progeny. In addition, we show that embryonic RNAi of BmTrpA1 affects diapause hormone release during pupal-adult development. This study identifying a thermosensitive TRP channel that acts as a molecular switch for a relatively long-term predictive adaptive response by inducing an alternative phenotype to seasonal polyphenism is unique. |
| 巻・号 | 111(13) |
| ページ | E1249-55 |
| 公開日 | 2014-4-1 |
| DOI | 10.1073/pnas.1322134111 |
| PII | 1322134111 |
| PMID | 24639527 |
| PMC | PMC3977306 |
| MeSH | Animals Body Weight Bombyx / embryology* Bombyx / genetics Bombyx / metabolism* Diapause, Insect / genetics* Embryo, Nonmammalian / metabolism* Embryonic Development / genetics Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockdown Techniques HEK293 Cells Humans Inheritance Patterns / genetics* Insect Proteins / genetics Insect Proteins / metabolism* Ion Channel Gating Molecular Sequence Data Neuroendocrine Cells / cytology Neuroendocrine Cells / metabolism Neuropeptides / metabolism Phenotype Pupa / cytology Pupa / metabolism RNA Interference TRPC Cation Channels / genetics TRPC Cation Channels / metabolism* Temperature* |
| IF | 9.412 |
| 引用数 | 27 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カイコ | |