| RRC ID |
29701
|
| 著者 |
Sato A, Sokabe T, Kashio M, Yasukochi Y, Tominaga M, Shiomi K.
|
| タイトル |
Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
In the bivoltine strain of the silkworm, Bombyx mori, embryonic diapause is induced transgenerationally as a maternal effect. Progeny diapause is determined by the environmental temperature during embryonic development of the mother; however, its molecular mechanisms are largely unknown. Here, we show that the Bombyx TRPA1 ortholog (BmTrpA1) acts as a thermosensitive transient receptor potential (TRP) channel that is activated at temperatures above ∼ 21 °C and affects the induction of diapause in progeny. In addition, we show that embryonic RNAi of BmTrpA1 affects diapause hormone release during pupal-adult development. This study identifying a thermosensitive TRP channel that acts as a molecular switch for a relatively long-term predictive adaptive response by inducing an alternative phenotype to seasonal polyphenism is unique.
|
| 巻・号 |
111(13)
|
| ページ |
E1249-55
|
| 公開日 |
2014-4-1
|
| DOI |
10.1073/pnas.1322134111
|
| PII |
1322134111
|
| PMID |
24639527
|
| PMC |
PMC3977306
|
| MeSH |
Animals
Body Weight
Bombyx / embryology*
Bombyx / genetics
Bombyx / metabolism*
Diapause, Insect / genetics*
Embryo, Nonmammalian / metabolism*
Embryonic Development / genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Knockdown Techniques
HEK293 Cells
Humans
Inheritance Patterns / genetics*
Insect Proteins / genetics
Insect Proteins / metabolism*
Ion Channel Gating
Molecular Sequence Data
Neuroendocrine Cells / cytology
Neuroendocrine Cells / metabolism
Neuropeptides / metabolism
Phenotype
Pupa / cytology
Pupa / metabolism
RNA Interference
TRPC Cation Channels / genetics
TRPC Cation Channels / metabolism*
Temperature*
|
| IF |
9.412
|
| 引用数 |
27
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| カイコ |
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