Reference - Detail
| RRC ID | 30073 |
|---|---|
| Author | Demple B, Halbrook J, Linn S. |
| Title | Escherichia coli xth mutants are hypersensitive to hydrogen peroxide. |
| Journal | J Bacteriol |
| Abstract |
Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-induced lethality and the in vivo role of exonuclease III. |
| Volume | 153(2) |
| Pages | 1079-82 |
| Published | 1983-2-1 |
| DOI | 10.1128/jb.153.2.1079-1082.1983 |
| PMID | 6337115 |
| PMC | PMC221738 |
| MeSH | Catalase / metabolism Escherichia coli / drug effects* Escherichia coli / enzymology Escherichia coli / genetics Exodeoxyribonucleases / physiology* Hydrogen Peroxide / pharmacology* Mutation Phenotype |
| IF | 3.006 |
| Times Cited | 191 |
| WOS Category | MICROBIOLOGY |
| Resource | |
| Prokaryotes E. coli | ME7765 |