RRC ID 30142
著者 Hong X, Cadwell GW, Kogoma T.
タイトル Activation of stable DNA replication in rapidly growing Escherichia coli at the time of entry to stationary phase.
ジャーナル Mol Microbiol
Abstract The conditions are described in which DNA replication can occur, in the absence of protein synthesis, in wild-type Escherichia coli cells. Chromosome replication, which is normally inhibited by addition of chloramphenicol, becomes resistant to this drug after nutritional shiftup, e.g. from minimal medium to Luria broth. This replication activity appears transiently when nutritionally upshifted cells enter stationary phase. The activity strictly requires recA+, but it is independent of recB+ and dnaA+. It can occur in the absence of concomitant transcription. Activation of the replication does not result from induction of the SOS response. As the characteristics of this DNA replication resemble those of the previously characterized stable DNA replication, it is termed nutritional shiftup-activatable stable DNA replication, nSDR. Possible mechanisms of the activation of nSDR in rapidly growing cells at the time of entry to stationary phase are discussed.
巻・号 21(5)
ページ 953-61
公開日 1996-9-1
DOI 10.1046/j.1365-2958.1996.591419.x
PMID 8885266
MeSH Bacterial Proteins / genetics Bacterial Proteins / metabolism Cell Division Chloramphenicol / pharmacology Chromosomes, Bacterial / genetics DNA Replication* DNA, Bacterial / biosynthesis* DNA-Binding Proteins / metabolism Escherichia coli / drug effects Escherichia coli / genetics* Escherichia coli / growth & development* Escherichia coli Proteins* Exodeoxyribonuclease V Exodeoxyribonucleases / metabolism Mutation Protein Synthesis Inhibitors / pharmacology Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins / metabolism Rec A Recombinases / metabolism Sigma Factor / genetics Sigma Factor / metabolism Wnt Proteins Zebrafish Proteins*
IF 3.418
引用数 17
WOS 分野 MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
原核生物(大腸菌) ME9572 ME9542 ME9500 ME9394 ME9264 ME9595 ME9596 ME9273 ME9473 ME9574