Reference - Detail
| RRC ID | 30411 |
|---|---|
| Author | Nishida Y, Hata M, Ayaki T, Ryo H, Yamagata M, Shimizu K, Nishizuka Y. |
| Title | Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene. |
| Journal | EMBO J |
| Abstract |
The genomic and cDNA fragments of Drosophila melanogaster, homologous to human c-raf-1, were cloned. The nucleotide sequence predicted the primary structure of a polypeptide of 666 amino acid residues with a highly conserved Ser-Thr kinase domain on its carboxy terminal half. Draf-1 was mapped to the 2F region of the X chromosome. Two newly induced recessive lethals belonging to a complementation group in this region were identified to be defective in Draf-1 by P element-mediated rescue experiments. The mutants die at larval/pupal stages. The mutant larvae are apparently normal, but they harbor serious defects in the organs containing proliferating cells of both somatic and germ line origins. Maternal effects on embryogenesis indicated that Draf-1 is also required in early larval development. |
| Volume | 7(3) |
| Pages | 775-81 |
| Published | 1988-3-1 |
| DOI | 10.1002/j.1460-2075.1988.tb02875.x |
| PMID | 3135183 |
| PMC | PMC454391 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cell Division Chromosome Mapping DNA / analysis DNA / genetics* Drosophila melanogaster / cytology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Extrachromosomal Inheritance Genes Humans Molecular Sequence Data Mutation Phenotype Proto-Oncogene Mas Proto-Oncogene Proteins / analysis Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins / metabolism Proto-Oncogene Proteins / physiology Proto-Oncogene Proteins c-raf Stem Cells / cytology* Stem Cells / drug effects Transfection |
| IF | 9.889 |
| Times Cited | 135 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Drosophila | DGRC#109803 |