| RRC ID |
30414
|
| Author |
Inoue H, Baba H, Awano K, Yoshikawa K.
|
| Title |
Genotoxic effect of griseofulvin in somatic cells of Drosophila melanogaster.
|
| Journal |
Mutat Res
|
| Abstract |
Griseofulvin (GF), a carcinogenic spindle poison, was tested in two types of somatic-cell assays of Drosophila melanogaster, one of which detects the induction of DNA damage and the other mutation/mitotic recombination. In both assays, GF was fed to tester larvae and genetic endpoints examined after emergence. In the wing spot test, trans-heterozygous flies carrying mwh and flr3 wing-hair mutations produced both significant and dose-dependent increases in the frequency of mwh single spots over the control level but no increase of twin spots. In the DNA repair test, double-mutant larvae carrying both mei-9(a) (excision repair-defective) and mei-41(D5) (postreplication repair-defective) mutations showed hypersensitivity to killing by GF compared with their DNA repair-proficient counterparts, suggesting that GF caused potentially lethal DNA damages which were efficiently repaired by the DNA repair-proficient but not -defective larvae. These lines of evidence clearly demonstrate that GF is genotoxic in somatic cells of Drosophila. It is noted that (1) GF-fed larvae showed a developmental delay and (2) surviving adult flies had morphological abnormalities in their eyes and wings.
|
| Volume |
343(4)
|
| Pages |
229-34
|
| Published |
1995-7-1
|
| DOI |
10.1016/0165-1218(95)90018-7
|
| PII |
0165-1218(95)90018-7
|
| PMID |
7623877
|
| MeSH |
Animals
Crossing Over, Genetic
DNA Damage*
DNA Repair / genetics
DNA Replication / genetics
Dose-Response Relationship, Drug
Drosophila melanogaster / drug effects
Drosophila melanogaster / genetics*
Female
Fertility
Genes, Insect
Griseofulvin / toxicity*
Heterozygote
Larva
Male
Mutagenicity Tests
Mutagens / toxicity*
Mutation
|
| IF |
2.463
|
| Times Cited |
3
|
|
WOS Category
|
TOXICOLOGY
GENETICS & HEREDITY
|
| Resource |
| Drosophila |
DGRC#109611 |
