論文 - 詳細
| RRC ID | 30418 |
|---|---|
| 著者 | Hoshino M, Matsuzaki F, Nabeshima Y, Hama C. |
| タイトル | hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein. |
| ジャーナル | Neuron |
| Abstract |
We have identified a gene, hikaru genki (hig), whose mutant phenotype includes abnormal locomotor behavior. Mutant first instar larvae have uncoordinated movements, and both larvae and adults have reduced locomotion. Sequence analyses revealed that this gene encodes a novel type of protein with a signal sequence, but without transmembrane regions. One of its domains has similarities with immunoglobulin domains; three or four regions are similar to a complement-binding domain found in complement-related proteins and selectins. In situ hybridization to embryos revealed that accumulation of the hig transcripts is restricted to subsets of cells in the CNS. Our data suggest that hig has a role in the development of CNS functions involved in locomotor activity. |
| 巻・号 | 10(3) |
| ページ | 395-407 |
| 公開日 | 1993-3-1 |
| DOI | 10.1016/0896-6273(93)90329-p |
| PII | 0896-6273(93)90329-P |
| PMID | 8461133 |
| MeSH | Amino Acid Sequence Animals Animals, Genetically Modified Base Sequence Central Nervous System / cytology Central Nervous System / physiology* Chromosome Mapping Drosophila / embryology Drosophila / genetics* Drosophila Proteins* Embryo, Nonmammalian / metabolism Gene Expression Genes, Insect* Locomotion* Molecular Sequence Data Movement Disorders / genetics* Mutation Nerve Tissue Proteins / genetics* RNA, Messenger / metabolism Sequence Homology, Amino Acid Transcription, Genetic |
| IF | 14.415 |
| 引用数 | 34 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109573 DGRC#109581 |