Reference - Detail
| RRC ID | 30479 |
|---|---|
| Author | Yagi Y, Nishida Y, Ip YT. |
| Title | Functional analysis of Toll-related genes in Drosophila. |
| Journal | Dev Growth Differ |
| Abstract |
The Drosophila genome encodes a total of nine Toll and related proteins. The immune and developmental functions of Toll and 18Wheeler (18W) have been analyzed extensively, while the in vivo functions of the other Toll-related proteins require further investigation. We performed transgenic experiments and found that overexpression of Toll-related genes caused different extents of lethality and developmental defects. Moreover, 18w, Toll-6, Toll-7 and Toll-8 often caused related phenotypic changes, consistent with the idea that these four genes have more conserved molecular structure and thus may regulate similar processes in vivo. Deletion alleles of Toll-6, Toll-7 and Toll-8 were generated by targeted homologous recombination or P element excision. These mutant alleles were viable, fertile, and had no detectable defect in the inducible expression of antimicrobial peptide genes except for the Toll-8 mutant had some defects in leg development. The expression of 18w, Toll-7 and Toll-8 mRNA showed wide and overlapping patterns in imaginal discs and the 18w, Toll-8 double and Toll-7, Toll-8 double mutants showed substantially increased lethality. Overall our results suggest that some of the Toll-related proteins, such as 18W, Toll-7 and Toll-8, may have redundant functions in regulating developmental processes. |
| Volume | 52(9) |
| Pages | 771-83 |
| Published | 2010-12-1 |
| DOI | 10.1111/j.1440-169X.2010.01213.x |
| PMID | 21158756 |
| PMC | PMC4017902 |
| MeSH | Alleles Animals Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Genes, Insect / genetics* Mutation Phenotype Toll-Like Receptors / genetics* |
| IF | 1.723 |
| Times Cited | 31 |
| WOS Category | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#109795 |