論文 - 詳細
| RRC ID | 30677 |
|---|---|
| 著者 | De Gregorio E, Han SJ, Lee WJ, Baek MJ, Osaki T, Kawabata S, Lee BL, Iwanaga S, Lemaitre B, Brey PT. |
| タイトル | An immune-responsive Serpin regulates the melanization cascade in Drosophila. |
| ジャーナル | Dev Cell |
| Abstract |
In arthropods, the melanization reaction is associated with multiple host defense mechanisms leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activates the enzyme prophenoloxidase (PPO), which, in turn, catalyzes the synthesis of melanin. Here we report the biochemical and genetic characterization of a Drosophila serine protease inhibitor protein, Serpin-27A, which regulates the melanization cascade through the specific inhibition of the terminal protease prophenoloxidase-activating enzyme. Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization. |
| 巻・号 | 3(4) |
| ページ | 581-92 |
| 公開日 | 2002-10-1 |
| DOI | 10.1016/s1534-5807(02)00267-8 |
| PII | S1534-5807(02)00267-8 |
| PMID | 12408809 |
| MeSH | Amino Acid Sequence Animals Catechol Oxidase / immunology Catechol Oxidase / metabolism Drosophila Proteins / genetics Drosophila Proteins / immunology* Drosophila melanogaster / genetics Drosophila melanogaster / immunology* Enzyme Precursors / immunology Enzyme Precursors / metabolism Melanins / immunology Melanins / metabolism Molecular Sequence Data Mutation Serpins / genetics Serpins / immunology* Signal Transduction / immunology |
| IF | 10.092 |
| 引用数 | 249 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
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| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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