論文 - 詳細
| RRC ID | 30710 |
|---|---|
| 著者 | Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, So T. |
| タイトル | The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. |
| ジャーナル | Nat Immunol |
| Abstract |
The physiological functions of members of the tumor-necrosis factor (TNF) receptor (TNFR)-associated factor (TRAF) family in T cell immunity are not well understood. We found that in the presence of interleukin 6 (IL-6), naive TRAF5-deficient CD4(+) T cells showed an enhanced ability to differentiate into the TH17 subset of helper T cells. Accordingly, TH17 cell-associated experimental autoimmune encephalomyelitis (EAE) was greatly exaggerated in Traf5(-/-) mice. Although it is normally linked with TNFR signaling pathways, TRAF5 constitutively associated with a cytoplasmic region in the signal-transducing receptor gp130 that overlaps with the binding site for the transcription activator STAT3 and suppressed the recruitment and activation of STAT3 in response to IL-6. Our results identify TRAF5 as a negative regulator of the IL-6 receptor signaling pathway that limits the induction of proinflammatory CD4(+) T cells that require IL-6 for their development. |
| 巻・号 | 15(5) |
| ページ | 449-56 |
| 公開日 | 2014-5-1 |
| DOI | 10.1038/ni.2863 |
| PII | ni.2863 |
| 解説 | HEK293T細胞に発現させ、IL6刺激によって引き起こされるSTAT3とIL6シグナル受容体gp130との結合、さらにTRAF5による阻害を調べるために使用されました。 |
| PMID | 24681564 |
| PMC | PMC4108451 |
| MeSH | Animals CD4 Antigens / metabolism Cell Differentiation / genetics Cells, Cultured Cytokine Receptor gp130 / metabolism* Disease Progression Encephalomyelitis, Autoimmune, Experimental / immunology* Interleukin-6 / immunology Mice Mice, Inbred Strains Mice, Knockout Myelin-Oligodendrocyte Glycoprotein / immunology Peptide Fragments / immunology STAT3 Transcription Factor / metabolism Signal Transduction / genetics T-Lymphocyte Subsets / immunology* TNF Receptor-Associated Factor 5 / genetics TNF Receptor-Associated Factor 5 / metabolism* Th17 Cells / immunology* Transcriptional Activation / genetics |
| IF | 20.479 |
| 引用数 | 24 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pEF-Flag-mSTAT3 (wild) (RDB02353). |