論文 - 詳細
| RRC ID | 30904 |
|---|---|
| 著者 | Kato M, Okanoya K, Koike T, Sasaki E, Okano H, Watanabe S, Iriki A. |
| タイトル | Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain. |
| ジャーナル | Brain Lang |
| Abstract |
Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular mechanisms underlying language impairments. |
| 巻・号 | 133 |
| ページ | 26-38 |
| 公開日 | 2014-6-1 |
| DOI | 10.1016/j.bandl.2014.03.007 |
| PII | S0093-934X(14)00045-5 |
| PMID | 24769279 |
| MeSH | Age Factors Animals Brain Brain Chemistry* Callithrix / genetics* Callithrix / physiology Disease Models, Animal* Dyslexia / genetics Dyslexia / physiopathology Female Forkhead Transcription Factors / genetics Gene Expression Profiling* Humans In Situ Hybridization Language Language Disorders / genetics* Language Disorders / physiopathology Male Membrane Proteins / genetics Microtubule-Associated Proteins / genetics Nerve Tissue Proteins / genetics Reading* Receptors, Immunologic / genetics Repressor Proteins / genetics Speech / physiology* Speech Disorders / genetics* Speech Disorders / physiopathology |
| IF | 2.339 |
| 引用数 | 20 |
| WOS 分野 | LINGUISTICS AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY PSYCHOLOGY, EXPERIMENTAL NEUROSCIENCES |
| リソース情報 | |
| 遺伝子材料 | Common marmoset EST clones. |